YAN, TIANHUA
Associate Professor of Department of physiology cardiovascularpharmacology, Institute of basic medicine and clinical pharmacy, China Pharmaceutical University
Phone: 13016931191
Email: 13016931191@126.com
Research Summary
Associate professor YAN was born in August 1969 in Wenling, Zhejiang Province. The main research directionis cardiovascular pharmacology, especially cardiovascular, cerebrovascular disease (such as coronary heart disease and cerebral apoplexy) and diabetes, which provide new methodsfor the research and development of new drugs. Heis engaged in cardiovascular pharmacology and new drug evaluation. He commitmentshis energy to theoretical teaching for Human Anatomy and Physiology, Cardiovascular Pharmacology and Modern Pharmacology, as well as the experimental teaching for undergraduate students. Collectively, Associate professor YAN is a excellent teacher with a sense of responsibility.
Education
2005-2008 Ph.D., Pharmacology，China Pharmaceutical University
1995-1998 M.S., Pharmacology，Second Military Medical University
1987-1991 B.S., Pharmacology，China Pharmaceutical University
Academic Experience
2006-nowAssociate professor of pharmacology, Department of physiology of China Pharmaceutical University
2005-2006Lecturer of pharmacology, Department of physiology of China Pharmaceutical University
1998-2004Department director of pharmacology, Department of Second Military Medical University
1991-1995Teaching assistant of pharmacology, Department of Nanjing Naval Medical College
Publications
2012, Human Anatomy and Physiology, Southeast University Press
Patents
1. Protective effect of compound on myocardial ischemia reperfusion injury in rats(200910025743.3)
2. Polypeptide CW7213 purification process(201110003682.8)
1. National Eleventh Five Major Drug Discovery Project.
Study on the effect of CW7213 on the treatment of diabetes mellitus.
2. National TwelveFive Major Drug Discovery Project.
Therapeutic effect of TG-6 on myocardial ischemia-reperfusion injury
3. National TwelveFive Major Drug Discovery Project.
Pharmacology and pharmacodynamics study of preclinical part of salidroside raw material.
Main Papers and Articles
1 Jingyan L, Yujuan G, Yiming Y, Lingpeng Z, Tianhua Y*, Mingxing M. Salidroside Attenuates LPS-Induced Acute Lung Injury in Rats[J].Inflammation.2017; 40(5):1520-1531.
2 Luo F, Liu J, Yan T*, Miao M.Salidroside alleviates cigarette smoke-induced COPD in mice[J].Biomedicine & Pharmacotherapy. 2017; 86:155-161.
3 Chen T, Ma Z, Zhu L, Jiang W, Wei T, Zhou R, Luo F, Zhang K, Fu Q, Ma C, Yan T*.Suppressing Receptor-Interacting Protein 140: a New Sight for Salidroside to Treat Cerebral Ischemia[J].Molecular Neurobiology. 2016; 53(9):6240-6250.
4.Zhou R, Luo F, Lei H, Zhang K, Liu J, He H, Gao J, Chang X, He L, Ji H, Yan T*, Chen T.Liujunzi Tang, a famous traditional Chinese medicine, ameliorates cigarette smoke-induced mouse model of COPD[J]. Journal of Ethnopharmacology 2016;193:643-651.
5.Chang X, Zhang K, Zhou R, Luo F, Zhu L, Gao J, He H, Wei T, Yan T*, Ma C.
Cardioprotective effects of salidroside on myocardial ischemia-reperfusion injury in coronary artery occlusion-induced rats and Langendorff-perfused rat hearts[J].International Journal of Cardiology. 2016; 15;215:532-44.
6 Qin Y, Zhang L, Xu Z, Zhang J, Jiang YY, Cao Y, Yan T*.Innate immune cellresponseupon Candida albicans infection.Virulence. 2016; 7(5):512-26.
7 Gao J, Zhou R, You X, Luo F, He H, Chang X, Zhu L, Ding X, Yan T*. Salidroside suppresses inflammation in a D-galactose-induced rat model of Alzheimer's disease via SIRT1/NF-κB pathway [J].Metabolic Brain Disease.2016, 31(4):771-8.
8 Zhu L, Chen T, Chang X, Zhou R, Luo F, Liu J, Zhang K, Wang Y, Yang Y, Long H, Liu Y, Yan T*, Ma C.Salidroside ameliorates arthritis-induced brain cognition deficits by?regulating Rho/ROCK/NF-κB pathway[J].Neuropharmacology, 2016; 103:
134-142
9 Jin Gao, He He, Wenjiao Jiang, Xiayun Chang, Lingpeng Zhu, Fen Luo, Rui Zhou, Chunhua Ma, Tianhua Yan*. Salidroside ameliorates cognitive impairment in a d-galactose-induced rat model of Alzheimer’s disease [J]. Behavioural Brain Research. 2015; 293: 27–33
10 Zhu L, Wei T, Gao J, Chang X, He H, Luo F, Zhou R, Ma C, Liu Y, Yan T*. The cardioprotective effect of salidroside against myocardial ischemia reperfusion injury in rats by inhibiting apoptosis and inflammation [J]. Apoptosis. 2015; 20(11):1433-1443
11 Xiayun Chang, Fen Luo, Wenjiao Jiang , Lingpeng Zhu, Jin Gao , He He , Tingting Wei, Shilin Gong, Tianhua Yan*. Protective activity of salidroside against ethanol
-induced gastric ulcer via the MAPK/NF-κB pathway in vivo and in vitro [J]. International Immunopharmacology. 2015; 28: 604–615
12 He He, Xiayun Chang, Jin Gao, Lingpeng Zhu, Mingxing Miao, Tianhua Yan* . Salidroside Mitigates Sepsis-Induced Myocarditis in Rats by Regulating IGF-1/PI3K/Akt/GSK-3β Signaling [J].Inflammation. 2015; 38(6):2178-84.
13 Ma C, Zhu L, Wang J, He H, Chang X, Gao J, Shumin W, Yan T*.
Anti-inflammatoryeffects of water extract of Taraxacum mongolicum hand.-Mazz on lipopolysaccharide-induced inflammation in acute lung injury by suppressing PI3K/Akt/mTOR signaling pathway[J]. Journal of Ethnopharmacology. 2015; 20; 168: 349-355