Xu Chi

                Publisher:基礎醫學Release time:2017-12-26Times of browsing:157

                Chi Xu, PhD.

                Dr. ChiXu was introduced as an Associate Professor in 2016. In 2005, he graduated from the college of life sciences in Zhejiang University, where he received his bachelor's degree. In the same year, he engaged in the research on neuropharmacology in Shanghai Institute of Materia Medica, Chinese Academy of Sciences, where he received his doctor’s degree in pharmacology in 2010. From 2011 to 2016, he worked as a postdoctoral associate in the Department of Pharmacology of the University of Minnesota Medical School. He studied the effects of addictive drugs on adult hippocampal neurogenesis in the lab of Dr. Horace H. Loh and Dr. Ping-Yee Law. Dr. Chi Xu’s research career has been proved by his publications on a number of renowned journals, such as Stem Cells, Cell Mol Life Sci, J Cell Sci, etc.He also served as a reviewer of scientific journals, including Stem Cells, J Cell Mol Life Sci, J Cell Mol Med, J Neurochem, Oncotarget, etc. Dr. Xu is now a member of the Societyfor Neuroscience.

                Publication List

                Xu, C.*, Loh, H.H., Law, P.Y., 2016. Effects of addictive drugs on adult neural stem/progenitor cells. Cell Mol Life Sci 73(2), 327-348.

                Xu, C.*, Zheng, H., Loh, H.H., Law, P.Y., 2015. Morphine promotes astrocyte-preferential differentiation of mouse hippocampal progenitor cells via PKCε-dependent ERK activation and TRBP phosphorylation. Stem Cells 33(9), 2762-2772.

                Xu, C.*, Zhang, Y., Zheng, H., Loh, H.H., Law, P.Y., 2014. Morphine modulates mouse hippocampal progenitor cell lineages by upregulating miR-181a level. Stem Cells 32(11), 2961-2972.

                Xu, C., Hong, M.H., Zhang, L.S., Hou, Y.Y., Wang, Y.H., Wang, F.F., Chen, Y.J., Xu, X.J., Chen, J., Xie, X., Ma, L., Chi, Z.Q., Liu, J.G., 2010. Serine 363 of the δ-opioid receptor is crucial for adopting distinct pathways to activate ERK1/2 in response to stimulation with different ligands. Journal of Cell Science 123, 4259-4270.

                Hong, M.H.#, Xu, C.#, Wang, Y.J., Ji, J.L., Tao, Y.M., Xu, X.J., Chen, J., Xie, X., Chi, Z.Q., Liu, J.G., 2009. Role of Src in ligand-specific regulation of delta-opioid receptor desensitization and internalization. Journal of Neurochemistry 108, 102-114.

                Zhang, Y., Kibaly, C., Xu, C., Loh, H.H., Law, P.Y., 2017. Temporal effect of manipulating NeuroD1 expression with the synthetic small molecule KHS101 on morphine contextual memory. Neuropharmacology 126, 58-69.

                Zhang, L., Kibaly, C., Wang, Y.J., Xu, C., Song, K.Y., McGarrah, P.W., Loh, H.H., Liu, J.G., Law, P.Y., 2017. Src-dependent phosphorylation of mu-opioid receptor at Tyr(336) modulates opiate withdrawal. EMBO Mol Med 9, 1521-1536.

                Zhang, Y., Xu, C., Zheng, H., Loh, H.H., Law, P.Y., 2016. Morphine Modulates Adult Neurogenesis and Contextual Memory by Impeding the Maturation of Neural Progenitors. PloS One 11, e0153628.

                Zhang, L.S., Wang, Y.J., Ju, Y.Y., Zan, G.Y., Xu, C., Hong, M.H., Wang, Y.H., Chi, Z.Q., Liu, J.G., 2015. Role for engagement of β-arrestin2 by the transactivated EGFR in agonist-specific regulation of delta receptor activation of ERK1/2. British Journal of Pharmacology 172, 4847-4863.