Wu Zhaoqiu

                Publisher:基礎醫學Release time:2017-12-26Times of browsing:192

                Curriculum Vitae


                 Zhao-Qiu Wu, Ph.D.

                 Professor and Principal Investigator

                 Department of Basic Medicine, School of Basic Medicine and Clinical Pharmacy

                 State Key Laboratory of Natural Medicines

                 Jiangsu Provincial Key Laboratory of Carcinogenesis and Intervention

                 China Pharmaceutical University

                 639 Longmian Ave., Nanjing 211193, China

                 Phone: +86-13809003346

                 Email: zqwu@cpu.edu.cn


                EDUCATION:

                09/1995 – 07/2000   Nanchang University, Bachelor Degree of Medicine

                09/2000 – 07/2003   China Pharmaceutical University, Master Degree of Pharmacology

                09/2003 – 07/2006   Chinese Academy of Sciences University, Ph.D. Degree of Pharmacology  


                POSTDOCTORAL TRANINING:

                 08/2006 – 08/2008 /  Research Fellow, Center for Cancer Research, Purdue University, West Lafayette, IN, USA

                 09/2008 – 10/2009   Research Fellow, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA


                ACADEMIC APPOINTMENTS:

                 11/2009 – 11/2014   Research Assistant Professor, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA

                 12/2014 – present /  /Professor, Department of Basic Medicine, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China

                 12/2015 – present / /  Professor, National Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China


                RESEARCH INTERESTS:

                 Tumor initiation and progression, cancer stem cells, transgenic mouse tumor models, targeted drug screening and R & D


                GRANT SUPPORT:

                1.  I.D. No.: NSFC 81572745 (NSFC, National Natural Science Foundation of China)

                 Role: Principal Investigator

                Title: Functional study of Snail1 in breast tumor initiation and progression Period: 01/2016 – 12/2019

                Direct cost: 620,000 Yuan (RMB)

                1. I.D. No.: NSFC 91539115 (NSFC, National Natural Science Foundation of China)

                Role: Principal Investigator

                Title: Role of Snail1/ MT1 signaling axis in neovascularization in atherosclerotic plaque

                Period: 01/2016 – 12/2018

                Direct cost: 800,000 Yuan (RMB)

                1. I.D. No.: BK20170029 (Jiangsu Provincial Natural Science Fund for Distinguished Young Scholar)

                Role: Principal Investigator

                Title: A Zeb1/p53 axis in stromal fibroblasts suppresses mammary epithelial tumors

                Period: 06/2017 – 06/2020

                Direct cost: 1,000,000 Yuan (RMB)

                1. I.D. No.: “Shuang-Chuang” Team Innovation Project (JiangSu provincial government)

                Role: Principal Investigator

                Title: Screening, research and development of novel peptides for cancer therapy

                Period: 01/2016 – 12/2018

                Direct cost: 1,000,000 Yuan (RMB)

                1. I.D. No.: “Shuang-Chuang” Individual Innovation Project (JiangSu provincial government)

                Role: Principal Investigator

                Title: Screening, research and development of novel immunotherapeutic drugs for cancer

                Period: 01/2017 – 12/2019

                Direct cost: 500,000 Yuan (RMB)

                1. I.D. No.: Endowment of Jiangsu Specially-Appointed Professor (JiangSu provincial government)

                Role: Principal Investigator

                Title: Molecular mechanisms for pathological angiogenesis in diseases

                Period: 01/2015 – 12/2017

                Direct cost: 500,000 Yuan (RMB)

                1. I.D. No.: The Start-up Fund from China Pharmaceutical University

                Role: Principal Investigator

                Title: Molecular mechanisms by which zinc finger transcriptional factors control malignant tumor initiation and progression and its targeted therapy

                Period: 01/2015 – 12/2020

                Direct cost: 4,600,000 Yuan (RMB)


                SCIENTIFIC ACTIVITIES:

                Editorial board

                Am. J. Physiol.-Gastrointest. Liver Physiol. (2010 – 2015)

                Associate editor

                Pathol. Res. Pract. (2017 – present)


                SELECTED PUBLICATIONS (*corresponding author)

                1. Ting Ni, Xiao-Yan Li, Na Lu, Teng An, Zhi-Ping Liu, Rong Fu, Wen-Cong Lv, Yi-Wei Zhang, Xiao-Jun Xu, R. Grant Rowe, Yong-Shun Lin, Amanda Scherer, Tamar Feinberg, Xiao-Qi Zheng, X. Shirley Liu, Qing-Long Guo, Zhao-Qiu Wu*, Stephen J. Weiss*. Snail1-Dependent p53 Repression Regulates Expansion and Activity of Tumor-Initiating Cells in Breast Cancer. Nat. Cell Biol., 2016, 18 (11): 1221-1232. IF: 20.1.

                2. Rong Fu, Yan Chen, Xiaoping Wang, Qinglong Guo*, Zhao-Qiu Wu*. Wogonin inhibits multiple myeloma-stimulated angiogenesis via c-Myc/VHL/HIF-1α signaling axis. Oncotarget, 2016, 7: 5715-5727. IF: 5.1.

                3. Zhao-Qiu Wu, Grant R Rowe, Kim-Chew Lim, Yongshun Lin, Yi Tang, Tamar Y Feinberg, Xiaoyan Li, Farideh Sabeh, Ivan Maillard, Stephen J Weiss*. A Snail1-Dll4/Notch Axis Controls Embryonic Vascular Development. Nat. Commun., 2014, 4 (5): 3998-4013. IF: 12.5.

                4. Zhao-Qiu Wu, Thomas Brabletz, Eric Fearon, Amanda L Willis, Casey Yuexian Hu, Xiaoyan Li, Stephen J Weiss*. The Canonical Wnt Suppressor, Axin2, Promotes Colon Carcinoma Oncogenic Activity. Proc. Natl. Acad. Sci., USA., 2012, 109 (28): 11312-11317. IF: 9.5.

                5. Zhao-Qiu Wu, Xiaoyan Li, Casey Y Hu, Michael Ford, Celina G Kleer, Stephen J Weiss*. Canonical Wnt signaling regulates Slug activity and links epithelial-mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression. Proc. Natl. Acad. Sci., USA., 2012, 109 (41): 16654-16659. IF: 9.5.

                6. Zhao-Qiu Wu, Xiaoqi Liu*. Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing. Proc. Natl. Acad. Sci., U.S.A.,2008, 105 (6): 1919-1924. IF: 9.5.

                7. Zhao-Qiu Wu, Xiaoming Yang, Greg Weber, Xiaoqi Liu*. Plk1 phosphorylation of TRF1 is essential for its binding to telomeric DNA. J. Biol. Chem., 2008, 283 (37): 25503-25513. IF: 5.8.



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