Qiang Lei

                Publisher:基礎醫學Release time:2017-12-26Times of browsing:195

                Lei Qiang, Ph.D

                Professor, School of Basic Medicine and Clinical Pharmacy

                State Key Laboratory of Natural Medicines

                China Pharmaceutical University

                Research Summary

                Study the mechanisms involved in and develop new strategy against non-melanoma skin cancer

                Skin cancer, especially the non-melanoma skin cancer, is the most common form of cancer in the world and approximately 40% of all malignancies, and the incidence has been steadily increasing over the last few decades. UVB induced DNA damage,hyperplasia, immunosuppression, dysregulated epidermal differentiation and skin inflammatory microenvironment is the main reason for non-melanoma skin cancer. Our lab focused on the mechanism involved in NER (nucleotide excision repair) which is important for elimination of UVB induced helix-distorting base lesions. We are also investigating the mechanism involved in UVB induced immunosuppression, dysregulated epidermal differentiation and skin inflammatory microenvironment, especially the correlation between epidermal and dermal cells after UVB radiation. Our findings have the potential to yield safe and efficient targets for treatment and prevention of UVB induced non-melanoma skin cancer.

                Investigate the role of autophagy in cancer and develop new strategy target autophagy and autophagy related genes for cancer treatment and prevention

                Autophagy is a catabolic process by which cellular proteins, cytoplasm, and organelles are captured and targeted for proteolytic degradation in lysosomes. The role of autophagy in tumor development is complex because it can be a tumor-promoting or -suppressing process. Our findings suggested that 1) the role of autophagy in different kind of cancer is different; 2) the role of autophagy in the initiation and progression of cancer is different; 3) the role of autophagy in different kind of cells in cancer microenvironment is different; 4) autophagy related gene has many autophagy independent function. Our findings may provide unique insights into the indispensable role of autophagy in cancer and facilitate the development of better chemopreventive and therapeutic strategies by targeting autophagy.

                Honors and Awards

                2011“Excellent Doctoral Dissertation of Jiangsu Province”

                2008 “Top 100 Most Cited Chinese Papers Published In International Journals”

                2012 “Top 100 Most Cited Chinese Papers Published In International Journals”

                2011 “Eli Lilly Asia Outstanding Graduate Thesis Award”

                2016 “Albert M. Kligman Travel Fellowship”


                National Natural Science Foundation of China, 81772911,2018-2021

                Jiangsu Natural Science Foundation, BK20170744,2017-2020

                Jiangsu ‘Six Peaks’ Talents Foundation, SWYY-095,2017-2020

                Jiangsu ‘Double Innovate Team’, 2017-2019

                 ‘Jiangsu Distinguished Professor, Excellent’, 2016-2019

                Research Start-up Fund for high-level talents, China Pharmaceutical University, 2016-2019

                Publication(* Corresponding Author)

                Qiang, Lei*, Ashley Sample, Han Liu, Xiao-yang Wuand Yu-Ying He*. Epidermal SIRT1 regulates inflammation, cell migration, and wound healing. Scientific Reports 7, no. 1 (2017): 14110

                Qiang, Lei*, Ashley Sample, Christopher R. Shea, Keyoumars Soltani, Kay F. Macleodand Yu-Ying He*. Autophagy gene ATG7 regulates ultraviolet radiation induced inflammation and skin tumorigenesis. Autophagy 2017

                Qiang, Lei, Baozhong Zhao, Palak Shah, Ashley Sample, Seungwon Yang and Yu-Ying He*. Autophagy positively regulates DNA damage recognition by nucleotide excision repair. Autophagy 12, no. 2 (2016): 357-368. 

                Qiang, Lei, Palak Shah, M H Barcellos-Hoff and Yu-Ying He*. TGF-β signaling links E-cadherin loss to suppression of nucleotide excision repair Oncogene 35, no. 25 (2016):3293-3302

                Qiang, Lei, Baozhong Zhao, Mei Ming, Ning Wang, Tong-Chuan He, Seungmin Hwang, Andrew Thorburn and Yu-Ying He*. Regulation of Cell Proliferation and Migration by P62 through Stabilization of Twist1. Proceedings of the National Academy of Sciences of the United States of America (PNAS) 111, no. 25 (2014): 9241-9246.

                Qiang, L., T. Wu, H-W Zhang, N. Lu, R. Hu, Y-J Wang, L. Zhao, F-H Chen, X-T Wang, Q-D You and Q-L Guo*. Hif-1 Alpha Is Critical for Hypoxia-Mediated Maintenance of Glioblastoma Stem Cells by Activating Notch Signaling Pathway. Cell Death and Differentiation 19, no. 2 (2012): 284-294.

                Qiang, Lei and Yu-Ying He*. Autophagy Deficiency Stabilizes Twist1 to Promote Epithelial-Mesenchymal Transition. Autophagy 10, no. 10 (2014): 1864-1865.

                Qiang, Lei, Chunli Wu, Mei Ming, Benoit Viollet and Yu-Ying He*. Autophagy Controls P38 Activation to Promote Cell Survival under Genotoxic Stress. Journal of Biological Chemistry 288, no. 3 (2013): 1603-1611.

                Qiang, Lei, Yong Yang, Yan-Jun Ma, Fei-Hong Chen, Ling-Bo Zhang, Wei Liu, Qi Qi, Na Lu, Lei Tao, Xiao-Tang Wang, Qi-Dong You and Qing-Long Guo*. Isolation and Characterization of Cancer Stem Like Cells in Human Glioblastoma Cell Lines. Cancer Letters 279, no. 1 (2009): 13-21.

                Qiang, Lei, Yong Yang, Qi-Dong You, Yan-Jun Ma, Lan Yang, Fei-Fei Nie, Hong-Yan Gu, Li Zhao, Na Lu, Qi Qi, Wei Liu, Xiao-Tang Wang and Qing-Long Guo*. Inhibition of Glioblastoma Growth and Angiogenesis by Garnbogic Acid: An in Vitro and in Vivo Study. Biochemical Pharmacology 75, no. 5 (2008): 1083-1092.

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                Address:  #639 Longmian Avenue, Jiangning District, Nanjing, 211198, P.R.China.